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KMID : 1140120060110020123
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Cancer Prevention Research
2006 Volume.11 No. 2 p.123 ~ p.128
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Antimutagenic and Cancer Cell Growth Inhibitory Effects of Sodium Alginate
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Cho Eun-Ju
Park Kun-Young
Lee Sook-Hee
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Abstract
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Antimutagenic and anticarcinogenic effects of sodium alginate were studied under Ames assay and cell culture system. Sodium alginate showed strong antimutagenicity against aflatoxin B1 (AFB1) and N-methyl-N’-nitro-N-nitrosoguanidine (MNNG) in Salmonella typhimurium TA100. At 5.0% concentration, sodium alginate exhibited 65 and 58% antimutagenicity against AFB1 and MNNG, respectively. In addition, sodium alginate inhibited the growth of AGS human gastric adenocarcinoma cells and HT-29 human colon carcinoma cells. The cancer cell growth inhibitory effect of sodium alginate was stronger than that of fucoidan, the well-known anticancer compound from seaweed. In particular, the growth
inhibitory effect of AGS cells was stronger than that of HT-29 cells. The growth of AGS and HT-29 cells was inhibited to 77 and 66%, respectively, by the treatment of sodium alginate 0.01%. On the other hands, sodium alginate did not affect the growth of Ac2F normal cells. It suggests that sodium alginate inhibits the growth of cancer cells selectively. The present study indicates that sodium alginate shows not only antimutagenic activity but also growth inhibitory effect on human cancer cells. (Cancer Prevention Res 11, 123-128, 2006)
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KEYWORD
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Sodium alginate, Antimutagenicity, Cancer cell, Fucoidan
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